Welcome, Guest. Please login or register.
March 29, 2024, 01:59:34 AM

Login with username, password and session length

Search:     Advanced search
we're back, baby
*
Home Help Search Login Register
f13.net  |  f13.net General Forums  |  General Discussion  |  Topic: Coronavirus / COVID-19 0 Members and 1 Guest are viewing this topic.
Pages: 1 ... 19 20 [21] 22 23 ... 40 Go Down Print
Author Topic: Coronavirus / COVID-19  (Read 251017 times)
Sky
Terracotta Army
Posts: 32117

I love my TV an' hug my TV an' call it 'George'.


Reply #700 on: May 23, 2020, 03:12:47 PM

3 houses with north of 6 cars parked in the road each (plus driveways packed) ON THIS BLOCK for bbqs today. Got an invite from my redneck buddies across the way for a brisket bbq tomorrow. It's over, right guys?

The fiancee and I are going to take her mom to her family's abandoned graveyard on the Tug Hill, far from any humans. Win.
Fabricated
Moderator
Posts: 8978

~Living the Dream~


WWW
Reply #701 on: May 23, 2020, 04:56:29 PM

Yeah, there's a nice chunk of the population that has basically declared this over. Whee.

"The world is populated in the main by people who should not exist." - George Bernard Shaw
Sky
Terracotta Army
Posts: 32117

I love my TV an' hug my TV an' call it 'George'.


Reply #702 on: May 23, 2020, 05:13:59 PM

Went to pick up a pizza, there are parties all over the city right now. Neat.
Sir T
Terracotta Army
Posts: 14223


Reply #703 on: May 23, 2020, 05:51:10 PM


Quote
BBC News: Coronavirus: Yemen's healthcare system 'in effect collapsed'

War-torn Yemen's healthcare system has "in effect collapsed" and coronavirus is spreading across the country, the United Nations has warned.

Jens Laerke, spokesman for the UN Office for the Co-ordination of Humanitarian Affairs (OCHA), described the situation as "extremely alarming".

He said people were being turned away from treatment centres partly because staff lacked protective equipment.

The Yemeni authorities have confirmed scores of infections, and 30 deaths.

But the UN says the real figures are almost certainly much higher.

The country's health system has been damaged by years of civil war and ventilators are in short supply.

Damn.

Hic sunt dracones.
Khaldun
Terracotta Army
Posts: 15157


Reply #704 on: May 23, 2020, 08:55:02 PM

So I don't want to understate the gravity of that report, but this is where we are maybe drifting into coronavirus tunnel-vision.

Yemen hasn't had a functioning health system throughout this entire war. That's why Saudi Arabia's bombing (with US support) has been so destructive--there is literally no humanitarian capacity on the ground but what NGOs provide.

Coronavirus is bad, but even at its worst, it's only a modest extra dose of misery on top of an already ghastly, miserable situation.
HaemishM
Staff Emeritus
Posts: 42628

the Confederate flag underneath the stone in my class ring


WWW
Reply #705 on: May 23, 2020, 09:32:12 PM

It likely wasn't the 'rona that tipped Yemen over the edge. It just swamped a pre-broken system.

jgsugden
Terracotta Army
Posts: 3888


Reply #706 on: May 23, 2020, 10:35:40 PM

I'm curious how many wealthy types are planning to isolate for the next 3 months while encouraging as many idiots as possible to get sick to limit the risk to their wealthy families down the road. 


2020 will be the year I gave up all hope.
Trippy
Administrator
Posts: 23612


Reply #707 on: May 24, 2020, 12:10:55 AM

Placebo-controlled trial of remdesivir has shown a modest benefit. Trial is sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.

Summary: median recovery time for those receiving drug was 11 days vs 15 days on placebo. Lower mortality rate was reported as well for remdesivir group but apparently that was not statistically significant. As is now typical regarding SARS-CoV-2/COVID-19 studies these results haven't been peer-reviewed yet.

NIAID annoncement:
https://www.niaid.nih.gov/news-events/nih-clinical-trial-shows-remdesivir-accelerates-recovery-advanced-covid-19

New York Times article:
https://www.nytimes.com/2020/04/29/health/gilead-remdesivir-coronavirus.html
Peer-reviewed version (which includes confidence intervals) is up now:

The New England Journal of Medicine: Remdesivir for the Treatment of Covid-19 — Preliminary Report

Some analysis of this version:

STAT (Boston Globe): Covid-19 study details benefits of treatment with remdesivir, and also its limitations

MedPage Today: Remdesivir Data from NIAID Trial Published — "Not a panacea" or a "cure-all," expert cautions

tl;dr Remdesivir worked best on the less severe patients. Those on high-flow oxygen, non-invasive mechanical ventilation, extracorporeal membrane oxygenation (ECMO) or invasive mechanical ventilation did only slightly better or slightly worse than the placebo group (see figure 2 in study). I.e. once the virus has established itself the anti-viral properties of remdesivir likely didn't show any reduced mortality since it's now the body's own immune system that's causing the most problems. There's also been criticism that the study criteria changed part way through and was also ended prematurely because the benefit was deemed significant enough that treatment should not be withheld from placebo subjects.

STAT: Inside the NIH’s controversial decision to stop its big remdesivir study

In more severe cases remdesivir will likely need to be combined with other drugs like anti-inflammatories to show a benefit. There's a double blind, randomized, placebo-controlled trial starting that combines remdesivir with the anti-inflammatory drug baricitinib to see if baricitinib combined with remdesivir works better than remdesivir alone (the placebo).

NIH Clinical Trial Testing Antiviral Remdesivir Plus Anti-Inflammatory Drug Baricitinib for COVID-19 Begins
Trippy
Administrator
Posts: 23612


Reply #708 on: May 24, 2020, 12:25:08 AM

More bad new for hydroxychloroquine. In the largest observational study to date hydroxychloroquine with or without a macrolide antibiotic like azithromycin showed increased mortality rates compared to the placebo group.

The Lancet: Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis

Study Analysis:

STAT: What a big new study on malaria drugs as Covid-19 treatments tells us — and what it doesn’t
Quote
“It’s a very striking finding and it’s convincing to me,” said Steven Nissen, a cardiologist at the Cleveland Clinic. “Based upon these findings and others, no one should take hydroxychloroquine with or without an antibiotic unless they are in a randomized controlled trial. It should not be used in the general population to prevent or to treat Covid-19 infection.”

Eric Topol, director and founder of the Scripps Research Translational Institute and a cardiologist, noted the risk in a series of tweets. “It’s no longer that hydroxychloroquine has no sign of efficacy,” he wrote, “it is associated with an increase in mortality.”
Trippy
Administrator
Posts: 23612


Reply #709 on: May 24, 2020, 12:31:20 AM

Reuters Exclusive: U.S. plans massive coronavirus vaccine testing effort to meet year-end deadline
Quote
CHICAGO (Reuters) - The United States plans a massive testing effort involving more than 100,000 volunteers and a half dozen or so of the most promising vaccine candidates in an effort to deliver a safe and effective one by the end of 2020, scientists leading the program told Reuters.

The project will compress what is typically 10 years of vaccine development and testing into a matter of months, testimony to the urgency to halt a pandemic that has infected more than 5 million people, killed over 335,000 and battered economies worldwide.

[...]

Candidates that demonstrate safety in small early studies will be tested in huge trials of 20,000 to 30,000 subjects for each vaccine, slated to start in July.
SurfD
Terracotta Army
Posts: 4035


Reply #710 on: May 24, 2020, 12:35:21 AM

Yeah, cause there isn't a hundred and one ways the Trump admin could possibly fuck something like that up.   If we are lucky, it will only be a small clusterfuck, but there is ample opportunity for it to turn into an epic shitshow as election day approaches and Trump gets more desperate for literally anything to throw to the masses.

Darwinism is the Gateway Science.
schild
Administrator
Posts: 60345


WWW
Reply #711 on: May 24, 2020, 07:25:46 AM

cool, that's a terrible idea i can't wait
HaemishM
Staff Emeritus
Posts: 42628

the Confederate flag underneath the stone in my class ring


WWW
Reply #712 on: May 24, 2020, 10:01:52 AM

I always wondered how we'd find a way to create the Rage Virus in real life. Now I know.

Cyrrex
Terracotta Army
Posts: 10603


Reply #713 on: May 24, 2020, 10:08:32 AM

You gotta figure that if they get 100,000 volunteers, almost all of them will be MAGAs.  I think it is a great plan.

"...maybe if you cleaned the piss out of the sunny d bottles under your desks and returned em, you could upgrade you vid cards, fucken lusers.." - Grunk
jgsugden
Terracotta Army
Posts: 3888


Reply #714 on: May 24, 2020, 12:28:34 PM

You gotta figure that if they get 100,000 volunteers, almost all of them will be MAGAs.  I think it is a great plan.
I don't see why. Most of them don't think the virus is a big deal. 

2020 will be the year I gave up all hope.
Gimfain
Terracotta Army
Posts: 553


Reply #715 on: May 24, 2020, 12:49:07 PM

What you have to ask yourself is if you find it acceptable the potential harm caused by advancing potential vaccines in this way or if you want to do the traditional way that will cause 10 to 50 million people world wide to die from covid-19 before we have a vaccine in 2030. The mass vaccination for the swine flu did cause a few people to have horrible side effects but it also prevented far more people from dying. When the safe route cause so much death you have to be willing to look for short cuts.

When you ask for a miracle, you have to be prepared to believe in it or you'll miss it when it comes
Reg
Terracotta Army
Posts: 5270


Reply #716 on: May 24, 2020, 12:55:09 PM

There's no way I'm using a vaccine that's been rushed out the door by a pharmaceutical company desperate for the money they gain from being first to market when the FDA has been forced to approve it by a corrupt head of state.

I'll wait for Health Canada to let me know if it's safe, thanks.
jgsugden
Terracotta Army
Posts: 3888


Reply #717 on: May 24, 2020, 01:05:43 PM

What you have to ask yourself is if you find it acceptable the potential harm caused by advancing potential vaccines in this way or if you want to do the traditional way that will cause 10 to 50 million people world wide to die from covid-19 before we have a vaccine in 2030. The mass vaccination for the swine flu did cause a few people to have horrible side effects but it also prevented far more people from dying. When the safe route cause so much death you have to be willing to look for short cuts.
If the thing sterilizes everyone that takes it after 5 years, it'd be a massive world changing horror. There is a reason for those long development cycles.   

2020 will be the year I gave up all hope.
schild
Administrator
Posts: 60345


WWW
Reply #718 on: May 24, 2020, 01:31:13 PM

What you have to ask yourself is if you find it acceptable the potential harm caused by advancing potential vaccines in this way or if you want to do the traditional way that will cause 10 to 50 million people world wide to die from covid-19 before we have a vaccine in 2030. The mass vaccination for the swine flu did cause a few people to have horrible side effects but it also prevented far more people from dying. When the safe route cause so much death you have to be willing to look for short cuts.
If the thing sterilizes everyone that takes it after 5 years, it'd be a massive world changing horror. There is a reason for those long development cycles.   

World improving horror

Pick something better than that, like everyone with an IQ over 80 gets brain cancer and dies
MahrinSkel
Terracotta Army
Posts: 10857

When she crossed over, she was just a ship. But when she came back... she was bullshit!


Reply #719 on: May 24, 2020, 01:35:48 PM

You know they're going to want to push something out before November. That means there is no long-term test group, and a lot of these are using technology that has never been used for humans. Some of them need all new distribution protocols.

It is not possible to put out a vaccine that quickly and know it is safe. It's barely possible to put it out with any confidence it even works.

--Dave

--Signature Unclear
HaemishM
Staff Emeritus
Posts: 42628

the Confederate flag underneath the stone in my class ring


WWW
Reply #720 on: May 24, 2020, 01:55:02 PM

I'm sure that third eye that grows on my ass cheek and also speaks in tongues will be totally safe and not in any way life-changing.

jgsugden
Terracotta Army
Posts: 3888


Reply #721 on: May 24, 2020, 02:07:55 PM

I'm sure that third eye that grows on my ass cheek and also speaks in tongues will be totally safe and not in any way life-changing.
Well, if it were a long tongue it certainly would be life-changing.

2020 will be the year I gave up all hope.
Sir T
Terracotta Army
Posts: 14223


Reply #722 on: May 24, 2020, 05:41:17 PM

What are you talking about? You can trust Grandfather Nurgle's guaranteed Vaccine.

Hic sunt dracones.
Sky
Terracotta Army
Posts: 32117

I love my TV an' hug my TV an' call it 'George'.


Reply #723 on: May 24, 2020, 09:06:29 PM

You gotta figure that if they get 100,000 volunteers, almost all of them will be MAGAs.  I think it is a great plan.
I don't see why. Most of them don't think the virus is a big deal.  
Was over at the neighbor's for a beer (me sitting away from the cluster of drunks). Had to leave once it got to 'it's all fake so Biden can win' 'my friend is a nurse who risked her license to say they are just letting people die in rooms to inflate the numbers' and 'we can't let communism win, goddamned socialists.'

I did point out that the guy in mid-rant was a government employee home on disability and his cheerleader has been home since November on unemployment and bitching that they were cutting him off.

These fucking people, man. I've never wanted so badly to not live in this country.

edited to add: and remember, I live in NY state, not Alabama. I can't imagine what it's like in gooberland.
HaemishM
Staff Emeritus
Posts: 42628

the Confederate flag underneath the stone in my class ring


WWW
Reply #724 on: May 24, 2020, 09:54:57 PM

Outside of major urban centers, it's ALL Alabama.  why so serious?

Surlyboi
Terracotta Army
Posts: 10962

eat a bag of dicks


Reply #725 on: May 24, 2020, 11:09:31 PM

The danger of a rushed vaccine is something like what they did with the swine flu vaccine back in '76 that gave a whole bunch people Guillain–Barré syndrome. I can see this bunch of chucklekfucks making something like that in a best-case scenario. I don't want to think about worst case.

As for people thinking it's over? Urban centers aren't safe either. I ventured out today and there were more maskless morons than I cared to count. I'm still making my mom stay home until fucking January at this point.

Tuned in, immediately get to watch cringey Ubisoft talking head offering her deepest sympathies to the families impacted by the Orlando shooting while flanked by a man in a giraffe suit and some sort of "horrifically garish neon costumes through the ages" exhibit or something.  We need to stop this fucking planet right now and sort some shit out. -Kail
Gimfain
Terracotta Army
Posts: 553


Reply #726 on: May 25, 2020, 05:32:22 AM

The danger of a rushed vaccine is something like what they did with the swine flu vaccine back in '76 that gave a whole bunch people Guillain–Barré syndrome. I can see this bunch of chucklekfucks making something like that in a best-case scenario. I don't want to think about worst case.
The only reason it was a mistake back then was because it was something mild, apply the same odds to something where the chance of dying is 1 in a 100 and the same thing would be viewed as a miracle, especially among older people where the odds of dying is 1 in 20 if they get it. Odds of me dying is somewhere around 1 in 2500 and with those odds it better be a safe vaccine.

When you ask for a miracle, you have to be prepared to believe in it or you'll miss it when it comes
Cyrrex
Terracotta Army
Posts: 10603


Reply #727 on: May 25, 2020, 08:12:44 AM

Trump has so poisoned his own FDA that I would trust nothing that comes from it while he is in office.  Better to look at authorities outside the US.

A fact which sadly applies to basically everything now.

"...maybe if you cleaned the piss out of the sunny d bottles under your desks and returned em, you could upgrade you vid cards, fucken lusers.." - Grunk
Mandella
Terracotta Army
Posts: 1235


Reply #728 on: May 25, 2020, 12:11:20 PM

You gotta figure that if they get 100,000 volunteers, almost all of them will be MAGAs.  I think it is a great plan.
I don't see why. Most of them don't think the virus is a big deal.  

edited to add: and remember, I live in NY state, not Alabama. I can't imagine what it's like in gooberland.

Goobers are goobers everywhere. I've been to upstate NY, felt right at "home."
Mandella
Terracotta Army
Posts: 1235


Reply #729 on: May 25, 2020, 12:13:55 PM

Trump has so poisoned his own FDA that I would trust nothing that comes from it while he is in office.  Better to look at authorities outside the US.

A fact which sadly applies to basically everything now.

Certainly not arguing your main point, but considering how many other countries are not exactly shining through as the bright shining hope on this, what authority would you suggest?

Honestly interest, not a snark.
Reg
Terracotta Army
Posts: 5270


Reply #730 on: May 25, 2020, 12:29:07 PM

I'm very sure of Health Canada. In the past we've trusted the FDA enough to rubber-stamp their decisions unless we had reason to doubt them (which we sometimes did.) That's just not going to happen anymore. If the government even tried there'd trouble. A fairly large majority of us have lost confidence in the USA. Our government may go on pretending that we're good buddies and allies but they aren't speaking for people who've been paying attention for the last few years.

The same applies to China and Saudi Arabia. We know they aren't our friends.
jgsugden
Terracotta Army
Posts: 3888


Reply #731 on: May 25, 2020, 12:55:12 PM

I feel like it doesn't matter who you ask, because our understanding is changing rapidly.  And, usually for the worse.  

Look at this article from April 23rd discussing papers written in a survey a week earlier.  Pay attention to those predictions. 19 Experts in public health and infectious disease predicted the total number of deaths about 2 weeks out (May 1) and then again about 7 weeks out (June 1) in the US. Out of 19 modelers, only *one* predicted expected deaths in the US above 105,000 by June 1.  9 of them said the upper bounds of how many deaths we could possibly face was going to be below 100,000 for June 1.  We passed 100,000 days ago, and should end up around 107,000 to 110,000 once you adjust for the shitty data trends that have deaths per day dropping off every weekend.

I think back to all of those nice bell curves they were predicting with a spike around mid-April and then things falling off as rapidly as they came upon us.  Ha.  My most commonly used source (IMHE) was predicting on April 1 that we'd not exceed 93,000 deaths. 

I've found nothing to trust, but still there are clear rules: Stay the fuck away from people.  Go our as rarely as possible.  Shop in the middle of the night, when possible, or right when stores open.  

« Last Edit: May 25, 2020, 01:03:05 PM by jgsugden »

2020 will be the year I gave up all hope.
schild
Administrator
Posts: 60345


WWW
Reply #732 on: May 25, 2020, 01:24:35 PM

i predicted a quarter million by summer

we're coming down to the wire

"thankfully" all the red states opened back up, so we're in for a party.... so to speak
HaemishM
Staff Emeritus
Posts: 42628

the Confederate flag underneath the stone in my class ring


WWW
Reply #733 on: May 25, 2020, 01:25:41 PM

It's becoming pretty clear that warm weather is not going to cause this one's infection rate to drop all that drastically.

Khaldun
Terracotta Army
Posts: 15157


Reply #734 on: May 25, 2020, 02:05:03 PM

One thing to watch is that a lot more of the cases popping up in the global South are people under 40. That could mean a lot of things, some of them just an indicator of general poor health in the under-40s, some of them that a lot of developing nations skew hard to younger populations (so that it is not per capita more under 40) or it could mean the virus is continuing to mutate or demonstrate new infection patterns.
Pages: 1 ... 19 20 [21] 22 23 ... 40 Go Up Print 
f13.net  |  f13.net General Forums  |  General Discussion  |  Topic: Coronavirus / COVID-19  
Jump to:  

Powered by SMF 1.1.10 | SMF © 2006-2009, Simple Machines LLC