Welcome, Guest. Please login or register.
March 28, 2024, 06:42:27 AM

Login with username, password and session length

Search:     Advanced search
we're back, baby
*
Home Help Search Login Register
f13.net  |  f13.net General Forums  |  General Discussion  |  Topic: Coronavirus / COVID-19 0 Members and 1 Guest are viewing this topic.
Pages: 1 ... 15 16 [17] 18 19 ... 40 Go Down Print
Author Topic: Coronavirus / COVID-19  (Read 250943 times)
Jeff Kelly
Terracotta Army
Posts: 6920

I'm an apathetic, hedonistic, utilitarian, nihilistic existentialist.


Reply #560 on: April 17, 2020, 04:02:41 PM

My 80 year old uncle is currently in a cancer ward after a tumor in his lung was removed, he suffers from a lung infection and pneumonia as complications from the operation. (Not Covid related). Pneumonia at this age is usually not a good sign, it’s usually an early indicator for multiple organ failure and death.

He probably doesn’t have a lot of time left and I’ll not be able to visit him. Or even attend his funeral if it came to him dying.

We didn’t have the best relationship but damn it sucks regardless. Thanks to this whole mess I won’t even be able to be with my family and my Dad (who is my uncle’s brother) during all of this.
jgsugden
Terracotta Army
Posts: 3888


Reply #561 on: April 17, 2020, 04:47:06 PM

The site is from The Institute for Health Metrics and Evaluation (IHME).  It is is an independent global health research center at the University of Washington.  I believe them to be independent and trying to project things as best they can.

There predictions have Deaths per Day dropping dramatically in California very soon.  That'll be a big indicator of how reasonable these estimates are.  You'll notice there is a huge range on the number of deaths per day possible for most states.  Michigan projects at 124, but the potential range is between 10 and 508.  Essentially, their numbers indicate that we're at the point where our isolation strategies should be having an impact on the number of deaths (as deaths occur weeks after infection and it has been several weeks since we took more drastic steps to isolate people).  That makes some sense. We may be on a decline at this point.  Until we lift the preventative measures and.... boom.

…. and Texas.  At least my state wasn't the first one to start rebuggering.

… and Silicon Valley. We just make technology.  Who needs math.
« Last Edit: April 17, 2020, 06:45:50 PM by jgsugden »

2020 will be the year I gave up all hope.
schild
Administrator
Posts: 60345


WWW
Reply #562 on: April 17, 2020, 07:01:59 PM

Texas isn't reopening. Read the plan. They're going to allow curbside pickup at retail. We ain't doin shit.
Trippy
Administrator
Posts: 23611


Reply #563 on: April 17, 2020, 07:17:36 PM

Not sure what the point of your title is. The Stanford study confirms what we already know which is that there's a lot of people out there who have had it and didn't know it either cause they never got tested or the test failed to detect it.
schild
Administrator
Posts: 60345


WWW
Reply #564 on: April 17, 2020, 09:34:21 PM

I've had a cough for nearly 2 weeks now.

It's not corona, but I really badly wish it was. Not even bothering getting tested because it's such a wet cough. Getting tested would *increase* my exposure.
eldaec
Terracotta Army
Posts: 11838


Reply #565 on: April 18, 2020, 02:52:51 AM

Plus if you get tested positive there is jack shit they can do about it.

I've been in the same position for the last couple of weeks, but then last few of days suddenly much worse, and my son suddenly had cough day 1, fever day 2, and now apparently fine. So... maybe... no clue really.

"People will not assume that what they read on the internet is trustworthy or that it carries any particular ­assurance or accuracy" - Lord Leveson
"Hyperbole is a cancer" - Lakov Sanite
jgsugden
Terracotta Army
Posts: 3888


Reply #566 on: April 18, 2020, 06:01:02 AM

Texas isn't reopening. Read the plan. They're going to allow curbside pickup at retail. We ain't doin shit.
I did.  Mostly about the lack of testing, honestly.  However, the two key words jumped out: "Incremental steps"

Texas will keep expanding action until they see the resurgence.

2020 will be the year I gave up all hope.
slog
Terracotta Army
Posts: 8232


Reply #567 on: April 18, 2020, 06:28:36 AM

Some positive news on the re-infection reporting

https://www.cnn.com/2020/04/17/health/south-korea-coronavirus-retesting-positive-intl-hnk/index.html

Quote
The KCDC has re-investigated three cases from the same family where patients tested positive after recovering, Kwon says.

In each of these cases, scientists tried to incubate the virus but weren't able to -- that told them there was no live virus present.
Like many countries, South Korea uses a reverse transcription polymerase chain reaction (RT-PCR) to test for the virus. The RT-PCR test works by finding evidence of a virus's genetic information -- or RNA -- in a sample taken from the patient.
According to Kwon, these tests may still be picking up parts of the RNA even after the person has recovered because the tests are so sensitive.


Friends don't let Friends vote for Boomers
schild
Administrator
Posts: 60345


WWW
Reply #568 on: April 18, 2020, 07:12:49 AM

Texas isn't reopening. Read the plan. They're going to allow curbside pickup at retail. We ain't doin shit.
I did.  Mostly about the lack of testing, honestly.  However, the two key words jumped out: "Incremental steps"

Texas will keep expanding action until they see the resurgence.
That requires the cities to play ball (spoiler: we won't)
schild
Administrator
Posts: 60345


WWW
Reply #569 on: April 18, 2020, 07:15:33 AM

Plus if you get tested positive there is jack shit they can do about it.

I've been in the same position for the last couple of weeks, but then last few of days suddenly much worse, and my son suddenly had cough day 1, fever day 2, and now apparently fine. So... maybe... no clue really.

Yeah, we had laryngitis or some bullshit come through the house (our symptoms were classic), but it has lasted longer than normal. Granted we didn't see a doctor or anything and are just letting it play out because we know it's functionally harmless. But man, having a cough for 2 weeks during Pangolin Lung Season is trash.
Trippy
Administrator
Posts: 23611


Reply #570 on: April 18, 2020, 10:40:56 AM

Some positive news on the re-infection reporting

https://www.cnn.com/2020/04/17/health/south-korea-coronavirus-retesting-positive-intl-hnk/index.html

Quote
The KCDC has re-investigated three cases from the same family where patients tested positive after recovering, Kwon says.

In each of these cases, scientists tried to incubate the virus but weren't able to -- that told them there was no live virus present.
Like many countries, South Korea uses a reverse transcription polymerase chain reaction (RT-PCR) to test for the virus. The RT-PCR test works by finding evidence of a virus's genetic information -- or RNA -- in a sample taken from the patient.
According to Kwon, these tests may still be picking up parts of the RNA even after the person has recovered because the tests are so sensitive.
However some of those testing positive again are also getting symptoms again too, albeit mild so far.

https://www.npr.org/sections/coronavirus-live-updates/2020/04/17/836747242/in-south-korea-a-growing-number-of-covid-19-patients-test-positive-after-recover
eldaec
Terracotta Army
Posts: 11838


Reply #571 on: April 18, 2020, 01:42:00 PM

Mild symptoms are indistinguishable from a regular cold though, so... I guess we know nothing.

"People will not assume that what they read on the internet is trustworthy or that it carries any particular ­assurance or accuracy" - Lord Leveson
"Hyperbole is a cancer" - Lakov Sanite
schild
Administrator
Posts: 60345


WWW
Reply #572 on: April 18, 2020, 01:51:03 PM

Mild symptoms are indistinguishable from a regular cold though, so... I guess we know nothing.

And this is why my shortly gonna hit 2 week cough makes me really hope it's corona. I'm not buying this "you don't get immunity" thing until it's proven without a doubt.
Brolan
Terracotta Army
Posts: 1395


Reply #573 on: April 18, 2020, 03:16:57 PM

If your body can't fight off the virus eventually then you would die from it, right?  So you must be building some form of immunity once you are infected.
jgsugden
Terracotta Army
Posts: 3888


Reply #574 on: April 18, 2020, 03:57:03 PM

There are a lot of angles to reinfection.  One would be whether the antibodies remain strong enough in the system to fight it off the next time.  Another would be if the virus tweaks itself fast enough that the antibodies you develop to fight it off in April are well suited to fight off the version you encounter in September.  There are a bunch of other angles.  You can find some online scholarly works on it (as opposed to the crap the media is releasing for clickbait).

There are a lot of stories out there from people that got this thing.  Some of them feature otherwise healthy people in their 30s and 40s that had it for a few weeks and barely showed any symptoms - and then were gone in a week.  It is a small percentage - but if you've played enough games, you know the really improbably turns up every once in a while.  You don't want to play games with this virus.  It may take a while to really get going in your lungs, but if your body just happens to have trouble fighting it off (which can happen to anyone) when it is in your lungs, you're looking at major permanent lung damage at best (shortening your life span and quality of life dramatically), and a week long painful descent into death at the other end of things.

2020 will be the year I gave up all hope.
Trippy
Administrator
Posts: 23611


Reply #575 on: April 30, 2020, 12:14:20 AM

Placebo-controlled trial of remdesivir has shown a modest benefit. Trial is sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.

Summary: median recovery time for those receiving drug was 11 days vs 15 days on placebo. Lower mortality rate was reported as well for remdesivir group but apparently that was not statistically significant. As is now typical regarding SARS-CoV-2/COVID-19 studies these results haven't been peer-reviewed yet.

NIAID annoncement:
https://www.niaid.nih.gov/news-events/nih-clinical-trial-shows-remdesivir-accelerates-recovery-advanced-covid-19

New York Times article:
https://www.nytimes.com/2020/04/29/health/gilead-remdesivir-coronavirus.html
Trippy
Administrator
Posts: 23611


Reply #576 on: April 30, 2020, 11:45:50 AM

Summary by Bill Gates of the vaccine development process and how it might play out for the COVID-19 vaccines:

https://www.gatesnotes.com/Health/What-you-need-to-know-about-the-COVID-19-vaccine
slog
Terracotta Army
Posts: 8232


Reply #577 on: April 30, 2020, 12:50:05 PM

Summary by Bill Gates of the vaccine development process and how it might play out for the COVID-19 vaccines:

https://www.gatesnotes.com/Health/What-you-need-to-know-about-the-COVID-19-vaccine


Maybe we get a vaccine for the common cold after all this is done. 

Friends don't let Friends vote for Boomers
Ashamanchill
Terracotta Army
Posts: 2274


Reply #578 on: April 30, 2020, 11:15:45 PM

There's like a hundred viruses associated with the common cold.

A poster signed by Richard Garriot, Brad McQuaid, Marc Jacobs and SmerricK Dart.  Of course it would arrive a couple years late, missing letters and a picture but it would be epic none the less. -Tmon
Cyrrex
Terracotta Army
Posts: 10603


Reply #579 on: May 01, 2020, 01:07:32 AM

There's like a hundred viruses associated with the common cold.

Obviously he means the REALLY COMMON cold.

"...maybe if you cleaned the piss out of the sunny d bottles under your desks and returned em, you could upgrade you vid cards, fucken lusers.." - Grunk
slog
Terracotta Army
Posts: 8232


Reply #580 on: May 01, 2020, 02:03:56 AM

There's like a hundred viruses associated with the common cold.

Sorry for looking for something positive.

Friends don't let Friends vote for Boomers
Sky
Terracotta Army
Posts: 32117

I love my TV an' hug my TV an' call it 'George'.


Reply #581 on: May 01, 2020, 11:27:43 AM

More like we'll now have Nyquil for covid19. The money is not in the cure, we live in a capitalist world. Now shut up and enter your payment info.
slog
Terracotta Army
Posts: 8232


Reply #582 on: May 01, 2020, 11:47:52 AM

More like we'll now have Nyquil for covid19. The money is not in the cure, we live in a capitalist world. Now shut up and enter your payment info.

If we get a vaccine for Covid-19 it will be the first vaccine for a Coronavirus and there would be tons of money for an annual common cold vaccine :)

Friends don't let Friends vote for Boomers
Trippy
Administrator
Posts: 23611


Reply #583 on: May 01, 2020, 12:02:27 PM

The coronaviruses that cause the common cold do account for a decent chunk of the infections, perhaps up to a 1/3rd. So if developing vaccines for coronaviruses becomes easier and (much) cheaper after all of this then perhaps somebody will make a vaccine for the 4 coronaviruses that cause the common cold.

Edit: sauces

https://www.cdc.gov/coronavirus/general-information.html
Quote
Common human coronaviruses, including types 229E, NL63, OC43, and HKU1, usually cause mild to moderate upper-respiratory tract illnesses, like the common cold

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3416289/
Quote
Epidemiological studies suggest that HCoVs account for 15 to 30% of common colds
« Last Edit: May 01, 2020, 12:08:22 PM by Trippy »
Khaldun
Terracotta Army
Posts: 15157


Reply #584 on: May 01, 2020, 02:09:59 PM

Yeah, I was pretty sure that rhinoviruses are most of what we call "the common cold".
Salamok
Terracotta Army
Posts: 2803


Reply #585 on: May 01, 2020, 05:11:21 PM

Texas isn't reopening. Read the plan. They're going to allow curbside pickup at retail. We ain't doin shit.

Reopening the Texas Economytm
Salamok
Terracotta Army
Posts: 2803


Reply #586 on: May 01, 2020, 05:20:37 PM

More like we'll now have Nyquil for covid19. The money is not in the cure, we live in a capitalist world. Now shut up and enter your payment info.

Just as long as it isn't regular Nyqil which contains dextromethorphan
Polysorbate80
Terracotta Army
Posts: 2044


Reply #587 on: May 01, 2020, 05:31:34 PM

.
« Last Edit: November 14, 2020, 04:22:19 AM by Polysorbate80 »

“Why the fuck would you ... ?” is like 80% of the conversation with Poly — Chimpy
NowhereMan
Terracotta Army
Posts: 7353


Reply #588 on: May 02, 2020, 04:26:03 AM

Placebo-controlled trial of remdesivir has shown a modest benefit. Trial is sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.

Summary: median recovery time for those receiving drug was 11 days vs 15 days on placebo. Lower mortality rate was reported as well for remdesivir group but apparently that was not statistically significant. As is now typical regarding SARS-CoV-2/COVID-19 studies these results haven't been peer-reviewed yet.

NIAID annoncement:
https://www.niaid.nih.gov/news-events/nih-clinical-trial-shows-remdesivir-accelerates-recovery-advanced-covid-19

New York Times article:
https://www.nytimes.com/2020/04/29/health/gilead-remdesivir-coronavirus.html


One of the researchers who worked on that does regular Instagram stories on stuff (@gutterkingbaby) and is well worth a follow. Hell might be worth creating an instagram account. She made the point that this whole study was funded by the NIH and if it shows positive outcomes keep a close on eye on Gilead's pricing for Remdesivir because they saved a ton of R&D costs not having to run the trial themselves and had the whole process massively streamlined for them by the US government.

"Look at my car. Do you think that was bought with the earnest love of geeks?" - HaemishM
Sky
Terracotta Army
Posts: 32117

I love my TV an' hug my TV an' call it 'George'.


Reply #589 on: May 02, 2020, 10:45:53 AM

More like we'll now have Nyquil for covid19. The money is not in the cure, we live in a capitalist world. Now shut up and enter your payment info.

Just as long as it isn't regular Nyqil which contains dextromethorphan
Sure.

Quote
“Sorting all that out, obviously, would be important,” he said. “But I just cannot imagine that this has a real impact on patients taking Robitussin.”
Trippy
Administrator
Posts: 23611


Reply #590 on: May 02, 2020, 12:40:28 PM

Placebo-controlled trial of remdesivir has shown a modest benefit. Trial is sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.

Summary: median recovery time for those receiving drug was 11 days vs 15 days on placebo. Lower mortality rate was reported as well for remdesivir group but apparently that was not statistically significant. As is now typical regarding SARS-CoV-2/COVID-19 studies these results haven't been peer-reviewed yet.

NIAID annoncement:
https://www.niaid.nih.gov/news-events/nih-clinical-trial-shows-remdesivir-accelerates-recovery-advanced-covid-19

New York Times article:
https://www.nytimes.com/2020/04/29/health/gilead-remdesivir-coronavirus.html
One of the researchers who worked on that does regular Instagram stories on stuff (@gutterkingbaby) and is well worth a follow. Hell might be worth creating an instagram account. She made the point that this whole study was funded by the NIH and if it shows positive outcomes keep a close on eye on Gilead's pricing for Remdesivir because they saved a ton of R&D costs not having to run the trial themselves and had the whole process massively streamlined for them by the US government.
Regardless of whether or not the NIH is helping funding these trials, Gilead will be under tremendous pressure to keep pricing "reasonable" if it turns out to be an effective treatment and better than the other alternatives being trialed. I.e. if Gilead tried to price it for maximum profits even the Republicans in Congress would be forced to do something about that. However I put reasonable in quotes cause it turns out that remdesivir is (currently) not easy to make so it may still be an expensive drug even "at cost". For an amusing read on what it takes to synthesize remdesivir check out: OMG! We Made One Gram Of Remdesivir!
Hawkbit
Terracotta Army
Posts: 5531

Like a Klansman in the ghetto.


Reply #591 on: May 04, 2020, 10:00:59 PM

Absolutely surreal video of an empty Seattle: https://www.youtube.com/watch?v=2qm9QZ_RzZc&feature=youtu.be

Of course they filmed early in the day to minimize traffic and people out an about. However, Seattle is the first city I lived in where there's *always* people out. This is just odd looking.
MahrinSkel
Terracotta Army
Posts: 10857

When she crossed over, she was just a ship. But when she came back... she was bullshit!


Reply #592 on: May 04, 2020, 10:11:17 PM

Absolutely surreal video of an empty Seattle: https://www.youtube.com/watch?v=2qm9QZ_RzZc&feature=youtu.be

Of course they filmed early in the day to minimize traffic and people out an about. However, Seattle is the first city I lived in where there's *always* people out. This is just odd looking.
I was a street urchin in Seattle 35 years ago. Even at 3-4 o'clock, there were always people about.

--Dave

--Signature Unclear
Khaldun
Terracotta Army
Posts: 15157


Reply #593 on: May 05, 2020, 10:09:28 AM

That remdesvir article was great, thank you for linking it.
Trippy
Administrator
Posts: 23611


Reply #594 on: May 05, 2020, 04:41:31 PM

Some recent information regarding Vitamin D and COVID-19.

A retrospective study done in Indonesia[1] (presumably non-peer reviewed) concluded that those studied with serum 25(OH)D (Vitamin D in the blood) of <=29 ng/ml had significantly higher death rates (7x - 10x) than those with >30 ng/ml. Note that since this wasn't a randomized double blind placebo controlled trial this is only correlation that's being shown here.

However there is a hypothesis that was recently proposed in a non-peer reviewed study[2] that Vitamin D may be suppressing the cytokine storm associated with more severe COVID-19 cases. This study used CRP levels as a proxy for Vitamin D levels since Vitamin D blood level measurements were unavailable so it's even more indirect.

Vitamin D plays an important part in our immune system[3] and has been shown in RDBPCTs to reduce the rates of acute respiratory tract infections among those with low levels of Vitamin D[4] so it wouldn't surprise me if it's shown that it has an effect(s) on COVID-19 as well.

Personally I've been taking a Vitamin D3 supplement daily since mid-2017 when I stopped going out regularly in the daytime so hopefully that's offering at least some protection. On average each additional 100 IU of Vitamin D3 will raise serum 25(OH)D by 1 ng/ml[5] so 2500 IU (a common supplement dosage amount here in the US) a day should may keep you above 30 ng/ml assuming a minimal amount being generated from some sunlight exposure or food sources.

However Vitamin D is a hormone and it's fat soluble (so you should take supplements with some fat) so excess amounts will stick around in your body unlike water-soluble vitamins like Vitamin C that you pee out so more is not necessarily better. In fact 25(OH)D >60 ng/ml may be associated with adverse effects[6] and even higher levels can be toxic.

Also you should not be taking medical advice from strangers on the Internet.

[1] Patterns of COVID-19 Mortality and Vitamin D: An Indonesian Study

[2] The Possible Role of Vitamin D in Suppressing Cytokine Storm and Associated Mortality in COVID-19 Patients

[3] Vitamin D and respiratory health

[4] Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data

[5] Vitamin D in health and disease

[6] Health Risks from Excessive Vitamin D
« Last Edit: May 05, 2020, 10:56:37 PM by Trippy »
Pages: 1 ... 15 16 [17] 18 19 ... 40 Go Up Print 
f13.net  |  f13.net General Forums  |  General Discussion  |  Topic: Coronavirus / COVID-19  
Jump to:  

Powered by SMF 1.1.10 | SMF © 2006-2009, Simple Machines LLC