I liked the grenade launcher damage upgrade against big daddies. The crossbow (you'll get later) has a damage and the ability to retrieve the bolts for upgrades. Pretty much makes it a sniper rifle with infinite ammo. The shotgun damage is helpful too, since again, it was one of the main ways I took down big daddies (electronic buck), otherwise I didn't use it a whole lot. I really wish the shotgun had an increased clip size.
I upgraded the pistol last. Chemical thrower right before it. I didn't use either of those very much.
The pistol just doesn't hold enough ammo. I don't think you get enough ammo storage for the shotty either so I went with the machine gun...smart move that was since the game has pretty much stopped giving me machine gun ammo after taking it all away during the Peaches event (I'm pretty bitter about that).
Also, is it me or did Atlas assume a whole fucking lot of me after the fun in the submarine bay? Hello? I just wanted out thanks??
"The world is populated in the main by people who should not exist." - George Bernard Shaw
I upgraded the shotgun damage and reduced the chemical thrower fuel usage the first two opportunities I got. With reduced fuel use + electric gel Big Daddy fights are pretty easy.
As for which plasmid + weapon to use, I liked Incinerate + Machine Gun. Incinerate leads off and does DoT while the MG whittles down health while I can see them. If they run away, that's fine - there's a good chance they'll drop due to the fire before they can reach the water or heal. Plus an burning enemy is an enemy who attacks you less.
Incinerate is generally cheaper on EVE than Electrobolt. TK can also be used to do some pretty good damage by throwing things at targets and it uses minimum EVE.
The chemical thrower is a good anti-Daddy weapon with the electric gel, because as long as the ammo holds out, your target's paralyzed. A couple of mines on the floor, an arrow to the head, he runs over the mines to get to me, then hose with electric gel until down.
The thrower was an underwhelming weapon but it was a nice topper-offer for big daddies.
I only ever had to use it in fluke circumstances, however. Trap bolts + mines would, for a significantly light amount of resources, take out any big daddy, since they are compelled to charge you pretty much no matter what. One corridor + one corner provides all the impetus for the big lugs to charge through several wires at you.
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