I don't remember which of the Naked Gun movies it comes from (and I'm probably misqouting it), but the most memorable one for me:
Somebody: Frank, you might wind up dead! Frank Drebin: "You Might Wind Up Dead" is my middle name.
"...maybe if you cleaned the piss out of the sunny d bottles under your desks and returned em, you could upgrade you vid cards, fucken lusers.." - Grunk